Those of us with a sweet tooth often struggle to find alternatives that aren’t packed with artificial sweeteners such as sucralose, aka Splenda. This seemingly innocent powder in the yellow packet (and in cough medicines, cookies and more) decreases the good bacteria in your gut; inhibits the absorption of certain medications; releases toxins during baking; and affects your body’s response to insulin, according to new research review published in the Journal of Toxicology and Environmental Health, Part B: Critical Reviews.